Proviral integration site for Moloney murine leukemia virus kinase (PIM kinase)

PIM kinases (Proviral integration site for Moloney murine leukemia virus kinases) are a family of serine/threonine protein kinases, including three isoforms: PIM1, PIM2, and PIM3. They were originally identified as common proviral integration sites in Moloney murine leukemia virus-induced lymphomas. PIM kinases regulate cell cycle progression, survival, and proliferation by phosphorylating substrates involved in oncogenic signaling pathways. Overexpression of PIM kinases has been observed in various cancers, such as prostate, breast, colon, and pancreatic cancer, and is associated with poor prognosis. These kinases are considered attractive therapeutic targets, and several small-molecule inhibitors and protein degradation strategies (PROTACs) are under preclinical and clinical investigation; no drugs targeting PIM kinases are currently approved. PIM kinases are generally non-essential in non-malignant cells, suggesting potential for targeted cancer therapy with limited toxicity[2].

Other names

PIM kinaseProto-oncogene serine/threonine-protein kinase Pim-1Pim-1 kinasePIM1PIM2PIM3Proto-oncogene proteins PIM

Inhibition of kinase catalytic activity (ATP-competitive inhibition), PROTAC-mediated proteolysis (targeted protein degradation)