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Target intelligence / Profile preview
Proviral Integration Site for Moloney Murine Leukemia Virus Kinase 1 (PIM1)
- Target
- PIM1
- Molecular classification
- Enzyme, Serine/threonine kinase, Proto-oncogene
01
Overview
PIM1 is a proto-oncogene encoding a serine/threonine kinase that is constitutively active and involved in cell survival, proliferation, and apoptosis. It is implicated in various cancers and is a target for therapeutic intervention.
02
Mechanism of action
Pim kinase inhibition
03
Biological functions
Cell survivalCell proliferationApoptosis inhibitionCell cycle progressionTranscriptional activation
04
Disease associations
CancerHematopoietic malignanciesProstate cancerSquamous cell carcinomaGastric cancerColorectal cancerPancreatic cancerBladder cancer
05
Safety considerations
Potential for off-target effects due to kinase family similarityResistance mechanisms may develop
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