Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Proviral Integration Site for Moloney Murine Leukemia Virus Kinase 2 (PIM2)
- Target
- PIM2
- Molecular classification
- Enzyme, Serine/threonine kinase, Proto-oncogene
01
Overview
PIM2 is a serine/threonine kinase that promotes cell survival and proliferation by inhibiting apoptosis. It is constitutively active and regulated by the JAK/STAT pathway. PIM2 acts as an oncogenic driver in various cancers, including hematological malignancies and solid tumors. Small molecule inhibitors targeting PIM2 are under development as potential cancer therapeutics.
- Other names
- Serine/threonine-protein kinase pim-2Pim-2 proto-oncogene, serine/threonine kinasepim-2 oncogenePim-2hproto-oncogene Pim-2 (serine threonine kinase)
02
Mechanism of action
Inhibition of kinase activity
03
Biological functions
Cell growthCell proliferationInhibition of apoptosisRegulation of signal transductionJAK/STAT pathway regulationNF-kB signaling
04
Disease associations
CancerHematological malignanciesLeukemiaSolid tumorsLiver cancerLung cancerProstate cancerBreast cancer
05
Safety considerations
Potential for off-target effectsDevelopment of resistanceHematological toxicities
06
Interacting drugs
SMI‑4a
2 more in the full profile.
Beyond the preview
Go deeper on Proviral Integration Site for Moloney Murine Leukemia Virus Kinase 2 (PIM2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Proviral Integration Site for Moloney Murine Leukemia Virus Kinase 2 (PIM2).