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Target intelligence / Profile preview
Proviral integration site for Moloney murine leukemia virus kinase 3 (PIM3)
- Target
- PIM3
- Molecular classification
- Enzyme, Serine/threonine-protein kinase
01
Overview
PIM3 is a proto-oncogene encoding a serine/threonine-protein kinase. It is part of the PIM family of kinases and plays critical roles in cell survival, apoptosis prevention, and protein translation. PIM3 promotes tumor growth and angiogenesis, regulates endothelial cell sprouting, and coordinates signal transduction pathways involved in the cell cycle, cytoskeletal rearrangement, and migration. Its overexpression contributes to tumorigenesis across various cancers, making it a drug target.
02
Mechanism of action
PIM3 kinase inhibitor
03
Biological functions
Regulation of cell survivalPrevention of apoptosisPromotion of protein translationRegulation of cell proliferationRegulation of cytoskeleton rearrangementAngiogenesis
04
Disease associations
Cancer
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