PRPF31 antisense RNA 1 (PRPF31-AS1)

PRPF31 antisense RNA 1 (PRPF31-AS1) is a long non-coding RNA (lncRNA) located on the opposite DNA strand to the PRPF31 gene and is transcribed in antisense orientation. While PRPF31 itself encodes an essential component of the spliceosome critical for pre-mRNA splicing and is directly linked to retinitis pigmentosa, PRPF31-AS1 does *not* encode a protein and has no well-established function or molecular target status. There is currently little to no evidence that PRPF31-AS1 functions as a conventional therapeutic target (such as a receptor, enzyme, transporter, etc.), nor is there evidence of clinical drugs or targeted therapies acting on it. Some lncRNAs are implicated in transcriptional or post-transcriptional gene regulation, but the roles of PRPF31-AS1 specifically are not described in the available literature. The vast majority of data and disease relevance is attributed to the *PRPF31* coding gene and not to its antisense transcript[1][2][3][7].\n\nKey reasons for is_incorrect = true:\n- PRPF31-AS1 is not a recognized drug target or therapeutic molecule; it is a non-coding RNA with no direct, established functional annotation as a target.\n- The primary disease association, mechanistic roles, and therapeutic efforts focus on PRPF31 (the protein-coding sense gene), not the antisense RNA.\n\nIf the intention was to reference the protein-coding PRPF31 gene, use “Pre-mRNA-processing factor 31 (PRPF31).” For PRPF31-AS1, information is extremely limited and not described as a target in disease biology, therapy, or drug interaction databases[1][2][3][7].

Other names

PRPF31-AS1antisense RNA to PRPF31