Pru p 3-specific CD4+ T-cell receptor (Pru p 3-specific TCR)

Pru p 3-specific CD4+ T-cell receptors are the primary mediators of the cellular immune response to Pru p 3, the major allergen in peach (Prunus persica). These receptors, located on the surface of CD4+ T helper cells, recognize specific peptide fragments of the Pru p 3 protein presented by Major Histocompatibility Complex (MHC) class II molecules. In allergic individuals, the interaction between these TCRs and Pru p 3 epitopes typically triggers a Th2-biased immune response, leading to the production of allergen-specific IgE and subsequent allergic inflammation. Pru p 3 is a non-specific lipid transfer protein (nsLTP) known for its high stability and potential to cause severe systemic reactions, including anaphylaxis. Targeting these TCRs through allergen-specific immunotherapy (AIT) aims to induce immune tolerance by promoting the expansion of regulatory T cells or shifting the cytokine profile toward a Th1-type response. Understanding the specific TCR repertoire and the dominant epitopes, such as Pru p 3 11-25 and 57-71, is crucial for developing safer and more effective peptide-based vaccines for peach allergy.

Other names

Peach allergen Pru p 3-specific TCRnsLTP-specific T-cell receptorPrunus persica allergen 3-specific TCR

Induction of peripheral T-cell tolerance, anergy, or immune deviation from a Th2-dominated response to a Th1 or regulatory T-cell (Treg) response through repeated exposure to specific Pru p 3 epitopes.