Prune homolog 2 with BCH domain (PRUNE2)

Prune homolog 2 with BCH domain (PRUNE2) encodes a large protein (~340 kDa) in the BCL2 and adenovirus E1B 19 kDa interacting family, characterized by a BCH domain at the carboxyl terminus. PRUNE2 is broadly expressed, particularly in neuronal and some epithelial tissues, and has a tumor-suppressive role supported by multiple studies in prostate, colorectal, and neural-derived cancers. The protein regulates apoptosis (via modulation of BCL2 family pathways and caspases), inhibits cell proliferation and invasion, and suppresses oncogenic transformation by modulating RhoA signaling and interacting with Nm23-H1, a metastasis suppressor. PRUNE2 expression is tightly regulated, including a unique mechanism involving antisense RNA (PCA3) and ADAR-mediated RNA editing in cancers. Reduced PRUNE2 expression is associated with poor prognosis and increased tumor proliferation, while overexpression induces apoptosis and cell cycle arrest. Altered promoter methylation and lncRNA regulation further impact PRUNE2's tumor suppressor function, making it a putative biomarker and candidate target in oncology. No drugs that directly interact with PRUNE2 are currently documented, nor are there established safety concerns related to its therapeutic modulation as of the current literature.

Other names

BMCC1BNIPXLC9orf65KIAA0367olfaxinprotein prune homolog 2BCH motif-containing molecule at the carboxyl terminal region 1BNIP2 motif-containing molecule at the C-terminal region 1A214N16.3bA214N16.3