Pruritus Pathway

The pruritus pathway refers to the complex network of molecular, cellular, and neural mechanisms responsible for the sensation of itch (pruritus). It involves both peripheral and central components, with multiple mediators, receptors, and signaling pathways contributing to the transmission and modulation of itch signals from the skin to the brain. Key components include primary sensory neurons, GPCRs (H1R, H4R, PAR2, PAR4), TRP channels (TRPV1, TRPA1), and cytokines (IL-4, IL-13, IL-31, TSLP). Dysregulation underlies many chronic itchy skin diseases.

Other names

Itch pathwayItch signaling pathway

Multiple, depending on the specific target within the pathway. Includes receptor antagonism (antihistamines), enzyme inhibition (JAK inhibitors), and receptor agonism (kappa opioid agonists).