Pseudogene similar to asparagine synthetase ASNS

ENSG00000226744 is a pseudogene with sequence similarity to the asparagine synthetase (ASNS) gene but does not encode an active enzyme[4]. Pseudogenes are typically non-coding and do not produce functional proteins; however, some pseudogenes are recognized to have regulatory influences on their parent genes or other genes via mechanisms such as antisense RNA production, competing endogenous RNA activity, or generation of noncoding RNAs[1]. There is no evidence that this pseudogene is implicated as a therapeutic target or is directly associated with disease pathogenesis or clinical interventions. Pseudogenes similar to known enzymes like ASNS may regulate the parent gene or related pathways at the transcript level, but do not have enzymatic activity and are not considered traditional drug targets[1][4]. No standardized abbreviation, aliases, or direct disease/drug associations specific to this pseudogene are established in curated databases[4]. The parent gene (ASNS), by contrast, encodes asparagine synthetase, which is involved in amino acid biosynthesis and has been associated with disorders like asparagine synthetase deficiency and is relevant in cancer metabolism research[2][3], but these associations do not extend to the pseudogene.