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This locus encodes a pseudogene—a DNA sequence with high homology to the F830045P16Rik gene found in rodents, but which lacks the ability to encode a functional protein product[1][2]. Pseudogenes typically arise from gene duplication or retrotransposition events and generally accumulate disabling mutations such as premature stop codons or frameshifts[2][3]. While most pseudogenes are regarded as nonfunctional genomic relics, in some cases, their RNA transcripts may play regulatory roles, such as acting as microRNA decoys, but there is no evidence that this particular pseudogene has such a role[4]. Pseudogenes are not considered therapeutic targets because they do not produce proteins and, unless function as regulatory RNAs is established, lack direct cellular functions suitable for pharmacological modulation[1][2][3].
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