Pseudogene similar to leukocyte immunoglobulin-like receptor

This gene, ENSG00000225370 (AC243962.1), is annotated as a **pseudogene similar to leukocyte immunoglobulin-like receptor** in Homo sapiens. Pseudogenes are genomic DNA sequences similar to normal genes but generally nonfunctional due to mutations, truncations, or other errors. This locus does not encode a functional protein and is not considered a therapeutic target. It shares homology with the family of leukocyte immunoglobulin-like receptors (LILRs), which comprise a group of regulatory receptors involved in immune modulation, but itself lacks a known protein product or biological activity, and is not implicated in immune signaling or disease[1][3][5]. **Notes and Justification:** - This entry is not a true drug target, nor is it a functional receptor, enzyme, or therapeutic molecule—it is a **pseudogene** with no evidence of protein expression or direct biological function[1][3]. - The description and aliases in gene databases confirm its status as a pseudogene; thus it is **not a target and is_incorrect (for therapeutic considerations) is true**[1][3][5]. - The pseudogene is called "leukocyte immunoglobulin-like receptor pseudogene 1" in some listings, but this is not a functional receptor[2][5]. - There are no drugs, mechanisms of action, or biomarker uses associated with this pseudogene. - For molecular and disease classification, "Other" is used because pseudogenes are generally cataloged separately from protein-coding genes and functional noncoding RNAs. **If an active, functional member of the leukocyte immunoglobulin-like receptor family is required (e.g., LILRB2, LILRA2), those are separate protein-coding genes with immune regulatory and disease relevance[4][6][7][9].**

Other names

AC243962.1leukocyte immunoglobulin-like receptor pseudogene 1LILRP1LILRA6PILT9CD85lGC19P055182additional GeneCards aliases