Pseudogene similar to membrane guanylyl cyclase

ENSG00000236796 is annotated as a "pseudogene similar to part of membrane guanylyl cyclase," indicating that it shares sequence similarity with functional guanylyl cyclase genes but is believed to be non-functional in humans[4]. In the mammalian genome, several membrane guanylyl cyclase genes exist (e.g., GUCY2D, GUCY2C), but some family members—including GC-D and GC-G—are pseudogenes in humans and do not produce functional proteins[1][4]. Functional membrane guanylyl cyclases act as receptors for natriuretic peptides and regulate synthesis of cyclic GMP in various tissues[1][2][3][5], but the pseudogenes have no known enzymatic activity or signaling function. The locus ENSG00000236796 does not correspond to any known therapeutic target and is not associated with disease or drug interaction.

Other names

membrane guanylyl cyclase pseudogene