Pseudogene similar to part of a ficolin family protein (ENSG00000232355)

ENSG00000232355 represents a pseudogene, a nonfunctional segment of DNA that resembles functional genes but lacks the ability to produce functional protein products. This specific pseudogene shows sequence similarity to ficolin family proteins, which are pattern recognition receptors involved in innate immunity, recognizing pathogen-associated molecular patterns and activating complement pathways. Functional ficolins consist of an N-terminal collagen-like domain and a C-terminal fibrinogen-like domain. ENSG00000232355, however, is characterized by loss of functionality and inability to produce active protein products. Pseudogenes are formed through various mechanisms including retrotransposition, segmental duplication with subsequent mutations, or direct inactivation of functional genes. While most are considered non-functional, some pseudogenes may retain regulatory functions, with studies suggesting that over 19% could potentially encode peptides, though their functional significance remains largely unknown. This particular pseudogene represents an evolutionary remnant related to the ficolin family.

Other names

ENSG00000232355 GenePseudogene Similar To Part Of A Ficolin Family Protein

Not applicable (pseudogene lacks functional protein product)