Pseudogene similar to part of alcohol dehydrogenase 5, chi polypeptid

This gene, ENSG00000228407, encodes a processed pseudogene with sequence similarity to the alcohol dehydrogenase 5 (ADH5) gene, specifically to the chi polypeptide class III enzyme. As a pseudogene, it contains mutations—including frameshifts and stop codons—that prevent translation into a functional protein. Processed pseudogenes lack introns and are typically formed via the retrotransposition of mRNA transcripts from their parental protein-coding genes, followed by reintegration and mutation in the genome. There is no evidence that this pseudogene produces a functional protein or is associated with disease processes; it is not a recognized therapeutic target[1][3][5][6]. Key context: - Pseudogenes are commonly annotated in the human genome but are generally not functional or therapeutically relevant. They may occasionally have regulatory roles as non-coding RNAs but this is gene- and context-dependent, and not established for ENSG00000228407[2][4][8]. - The parental gene, alcohol dehydrogenase 5 (ADH5), is a well-known enzyme involved in alcohol and formaldehyde metabolism, but this pseudogene shares sequence similarity only, without functional protein production[5][7]. Therefore, this entry is not a true molecular target for drugs, diagnostics, or therapeutic research.

Other names

RP4-800M22.1processed pseudogene of ADH5ADH5 pseudogene

None (no protein product; not druggable)