Pseudogene similar to part of cytochrome c oxidase subunit 3

ENSG00000230112 refers to a pseudogene—a segment of DNA similar to part of the mitochondrial cytochrome c oxidase subunit III (MTCO3), but incorporated into the nuclear genome[1][4]. As a pseudogene, it is a non-functional remnant of a once-coding gene; it does not encode a functional protein and has no known direct biological function or disease association[1][4]. Pseudogenes like this, known as "nuclear mitochondrial DNA segments" (NUMTs), pose a notable challenge in molecular genetics, especially in DNA barcoding and genomic studies, because they can be mistakenly amplified instead of authentic mitochondrial genes, leading to erroneous interpretations[4]. ENSG00000230112 is not considered a therapeutic target, receptor, enzyme, transporter, or any other class of druggable target: it is non-functional and not implicated in any mechanism of action or biomarker strategy. This entry is correctly identified as a pseudogene, specifically a nuclear-embedded, non-functional copy of mitochondrial gene sequence (NUMT)[1][4]. It is not an active part of the electron transport chain (unlike the functional MTCO3 gene/protein)[2][3]. The record is included in genomic databases for annotation purposes, typically to prevent confusion in molecular/genetic analyses[1][4]. ENSG00000230112 is not a druggable or functional molecular target, but a non-functional nuclear pseudogene resembling part of cytochrome c oxidase subunit 3[1][4].

Other names

Pseudogene similar to part of MTCO3Cytochrome c oxidase subunit III pseudogeneENSG00000230112