Pseudogene similar to part of melanoma antigen family proteins (ENSG00000237171 (no standard protein symbol; sometimes listed as AC005297.3[1]))

ENSG00000237171 is annotated as a "pseudogene similar to part of melanoma antigen family proteins" in humans[1][3]. Pseudogenes are genomic sequences derived from functional genes but have accumulated mutations that prevent them from producing functional proteins. This particular pseudogene shows sequence similarity to the MAGE (Melanoma Antigen Gene) family, which are cancer-testis antigens associated with various cancers and studied as diagnostic biomarkers and immunotherapy targets[4]. However, ENSG00000237171 itself does not encode any protein product, is not listed as a functional member of the MAGE family, and is not considered a receptor, enzyme, or other druggable target[1][3]. Thus, it is generally not referenced in the context of therapeutic targeting or disease biology. Summary of Key Issues: - ENSG00000237171 is a non-coding pseudogene and is not a true target molecule. - It is not a member of the canonical, functional MAGE family but is related by sequence. - No evidence supports its use as a biomarker, therapeutic target, or functional receptor, enzyme, or any other biochemically active protein. If you are seeking actionable information about MAGE family targets (such as MAGEA4), it would be advisable to research functional members of the MAGEA family rather than this pseudogene[4][5].

Other names

AC005297.3[1]