Pseudogene similar to part of mitochondrially encoded cytochrome c oxidase III (ENSG00000249780)

ENSG00000249780 is a pseudogene that shows sequence similarity to part of the mitochondrially encoded cytochrome c oxidase III (MT-CO3) gene. Pseudogenes are DNA sequences that resemble functional genes but are typically non-functional due to mutations that prevent proper gene expression or protein production. While the functional MT-CO3 gene encodes cytochrome c oxidase subunit III, which is a crucial component of the mitochondrial respiratory chain complex IV involved in cellular energy production, this pseudogene does not produce a functional protein. The actual MT-CO3 gene is located in the mitochondrial genome and encodes a 261-amino acid protein that serves as one of the three mitochondrial DNA-encoded subunits of respiratory complex IV. However, ENSG00000249780 represents only a pseudogene copy with sequence similarity to this important mitochondrial gene, making it not suitable as a therapeutic target.

Other names

MT-CO3 pseudogene