Pseudogene similar to part of mitochondrially encoded NADH dehydrogenase 2

This locus (ENSG00000228770) designates a pseudogene that shares high sequence similarity to the MT-ND2 gene. MT-ND2 encodes the NADH dehydrogenase 2 subunit of Complex I in the mitochondrial electron transport chain[1][2][3][4][6][7][8]. However, ENSG00000228770 itself does not produce a functional protein and does not participate in mitochondrial respiratory function, nor is it associated with disease or therapeutic targeting. By contrast, the functional MT-ND2 gene is implicated in neurodegenerative diseases (like Leigh syndrome and Leber hereditary optic neuropathy), mitochondrial disorders, and electron transport, but these roles do not extend to the pseudogene[1][2][3]. Note: - If your intent is to find structured information on the functional MT-ND2 gene, reference the Ensembl gene ENSG00000198763, which describes the true mitochondrial gene and not this pseudogene[3][5]. - This pseudogene entry does not meet typical criteria for a searchable or actionable drug target, and should be excluded from therapeutic target lists unless further validated functional relevance is discovered.

Other names

ENSG00000228770MT-ND2 pseudogene