Pseudogene similar to part of NADH dehydrogenase 5 MTND5

This gene, ENSG00000229830, is a pseudogene similar in sequence to a portion of the MT-ND5 gene, which encodes a subunit of mitochondrial complex I (NADH: ubiquinone oxidoreductase)[1][5]. Pseudogenes arise from gene duplication or retrotransposition events but have lost their protein-coding function due to disabling mutations. MTND5P23, as such, does not encode a protein and has no known biological activity, role in disease, or relevance for drug targeting or mechanism-of-action studies[1][5]. It is distinct from the functional mitochondrial gene MT-ND5, which is associated with several mitochondrial diseases[2][3][4], but the pseudogene itself is not biologically or clinically significant. If you are seeking information about the functional mitochondrial gene MT-ND5, it is a core component of complex I in the electron transport chain and is involved in diseases such as MELAS, Leigh syndrome, and Leber hereditary optic neuropathy. However, this pseudogene (ENSG00000229830 / MTND5P23) does not possess those functions and is not a therapeutic target[1][5].

Other names

MTND5P23MT-ND5 pseudogene 23ENSG00000229830Pseudogene similar to part of NADH dehydrogenase 5 MTND5