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This locus, ENSG00000237555, encodes a pseudogene with sequence similarity to part of the nucleotide binding protein (NBP) gene family, but it does not code for a functional protein[1][3]. Pseudogenes are genomic DNA sequences similar to known genes but are nonfunctional due to mutations or lack of regulatory elements required for transcription/translation[2][4][6]. They may be processed (lacking introns, arising from retrotransposition) or unprocessed[2][4][6]. Many pseudogenes are transcriptionally silent, but some can be transcribed and exert biological effects through regulatory RNA mechanisms (e.g., acting as competing endogenous RNAs or microRNA decoys), influencing expression of related genes in certain contexts, such as cancer[5][6][7]. There is no data indicating this particular pseudogene, ENSG00000237555, is functional or relevant as a therapeutic target.
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