Pseudogene similar to part of proteasome subunit beta type 5

ENSG00000230617 is a pseudogene that shows sequence similarity to part of the proteasome subunit beta type 5 (PSMB5). Pseudogenes are genomic segments resembling protein-coding genes but are generally nonfunctional, lacking the capability to encode a functional protein due to disabling mutations or missing regulatory elements[1][2][4]. Although many pseudogenes may have regulatory roles through their RNA products, most, including this one, are not established therapeutic targets, nor are they known to interact with drugs or serve as direct disease biomarkers[1][3][4]. Key context: - A pseudogene is not a functional gene, but a genomic DNA sequence similar to a functional gene, typically rendered nonfunctional by inactivating mutations[2][3][4]. - This pseudogene is related to the parent gene PSMB5, which encodes a critical enzymatic core subunit of the proteasome complex[5][6]; however, the pseudogene (ENSG00000230617) itself does not produce a functional proteasome subunit. - Pseudogenes as a class are rarely considered drug targets, and there is no evidence that this particular pseudogene functions as a target for therapeutics or is associated with diseases directly[1][2][3][4].

Other names

Pseudogene similar to part of proteasome (prosome, macropain) subunit, beta type, 5 PSMB5ENSG00000230617