Pseudogene similar to part of ribosomal protein L18a LOC100136354

"Pseudogene similar to part of ribosomal protein L18a LOC100136354" (ENSG00000248895) is a processed pseudogene derived from the ancestral ribosomal protein L18a (RPL18A) gene[7][1][3]. Pseudogenes are defined as DNA sequences similar to known genes but generally incapable of encoding functional proteins due to crippling mutations, truncation, or loss of regulatory elements[2][1]. Many ribosomal protein genes, including RPL18A, have numerous processed pseudogenes in the human genome produced by retrotransposition[4][1][6]. These pseudogenes typically do not produce proteins but may be transcribed and can sometimes affect gene regulation, for example by acting as microRNA decoys, producing non-coding RNAs, or rarely being translated into small peptides[1][9][5]. There is no evidence or precedent for this pseudogene being a direct therapeutic target, encoding a functional protein, or playing a defined role in disease or drug action. Notes on structure and naming: - The entity is not a functional gene or protein; it is a pseudogene sharing sequence similarity with RPL18A[7][3]. - RPL18A is a protein-coding gene encoding 60S ribosomal protein L18a, but ENSG00000248895 is a non-functional, processed pseudogene[6][8]. - No standard abbreviation for this pseudogene exists, and its designation is strictly as a pseudogene. - There is no established role as a receptor, enzyme, transporter, or any other class of druggable target. - Presence of the term "LOC100136354" and inconsistent nomenclature further mark this as a non-canonical, potentially outdated or low-utility entry[7]. Summary judgment: This is a **pseudogene** with no protein-coding potential, no established biological or therapeutic relevance, and is **not considered a therapeutic target**. Its inclusion as a target is **incorrect**. The entry has too little information for structured therapeutic annotation and should be flagged for review or exclusion[7][2].

Other names

ENSG00000248895GC17P046959GC17P046960GC17P046962GC17P046964Pseudogene similar to ribosomal protein L18a LOC100136354[7]