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ENSG00000237875 is a genomic locus annotated as a **pseudogene** with high sequence similarity to the functional human *ribosomal protein S3A (RPS3A)* gene. *Pseudogenes* are characterized by their lack of ability to produce functional proteins due to mutations or gene processing events, despite sequence homology to established protein-coding genes[2][5]. This pseudogene does not participate in ribosome function, protein synthesis, or biological regulation; it is a remnant of evolutionary gene duplication or retrotransposition and is generally considered part of the non-coding and nonfunctional fraction of the human genome. Care must be taken not to confuse this pseudogene with the bona fide RPS3A protein, which has established biological, disease, and potential therapeutic relevance[2][4][5].
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