Pseudogene similar to part of RIO kinase 2

ENSG00000231296 (also known as RP1-39G22.4) is a pseudogene that shows sequence similarity to a portion of the RIO kinase 2 (RIOK2) gene found in yeast and humans[1]. Pseudogenes are generally defined as gene-like DNA sequences that no longer produce a functional protein product because of disabling mutations. They arise by duplication or retrotransposition from functional genes, and many have no known biological function. Some pseudogenes can be transcribed to RNA and might be involved in gene regulation at the RNA level, but most are not therapeutically targeted or directly involved in disease[2][4][6]. There is no evidence that ENSG00000231296 encodes a functional protein, is a drug target, or acts as a biomarker. Its annotation as a "pseudogene similar to part of RIO kinase 2" means it is not the functionally relevant kinase RIOK2, which itself is a ribosome biogenesis factor and potential cancer target, but is instead a nonfunctional relic that may be useful for comparative genomics or evolutionary studies[1][4][6].

Other names

RP1-39G22.4pseudogene similar to part of RIO kinase 2 (yeast) (RIOK2)