Pseudogene similar to part of transmembrane protein 198

ENSG00000222024 is a **pseudogene** that shares sequence similarity with the gene encoding transmembrane protein 198 (TMEM198) but does not encode a protein product[3][7]. Pseudogenes are typically nonfunctional, often transcribed but not translated, and may regulate their parent or homologous genes through RNA-based mechanisms such as transcript competition or antisense interactions[5][9]. There is no evidence that ENSG00000222024 itself is a therapeutic target, receptor, enzyme, or related to drug interaction. However, dysregulated pseudogene expression has been reported in some cancer contexts, where the homology and possible transcript-based effects could indirectly influence disease progression[1][5][9]. Specific functional studies for this exact pseudogene are lacking. Essential notes: - ENSG00000222024 is *not* a protein-coding gene, nor is it a known therapeutic target[3][7][9]. - Its functional, protein-coding homolog is **TMEM198 (transmembrane protein 198)**, which is associated with Wnt signaling and cancer[2][8]; do not confuse the pseudogene with the functional gene. - TMEM198B may refer to a related functional pseudogene implicated in glioma biology[1], but it is distinct from ENSG00000222024. - No known drugs or clinical biomarkers are associated with ENSG00000222024. In summary, ENSG00000222024 is a nonfunctional pseudogene, not a therapeutic target, and should not be used as a primary molecular or drug discovery target[3][7][9].

Other names

TMEM198 pseudogeneTMEM198B (in some contexts, but TMEM198B may refer to another functional pseudogene)