Pseudomonas aeruginosa cell surface receptor (null)

The term “Pseudomonas aeruginosa cell surface receptor” encompasses a diverse group of proteins and complexes located in the outer membrane of *Pseudomonas aeruginosa*. These receptors include TonB-dependent transporters for iron/heme/siderophores uptake (e.g., FpvA, HasR, HxuA)[4][5], porins enabling nutrient and antibiotic diffusion (e.g., OprF, OprD)[6], and various signal transducers in cell surface signaling pathways (e.g., CSS components)[4][5]. Adhesins and pili serve in adherence to human tissues, promoting host colonization and biofilm formation[8]. Many of these surface receptors are critically involved in pathogenesis, including immune evasion, infection establishment, and resistance to host defenses and antibiotics[2][3][6]. Their diversity and adaptability make targeting these receptors for therapeutic and diagnostic purposes both promising and challenging; resistance mechanisms frequently arise via receptor modification or loss, and the multiplicity of receptor functions in virulence, signaling, and survival complicates intervention[6][7].

Other names

Cell surface receptor of Pseudomonas aeruginosaOuter membrane receptor of Pseudomonas aeruginosaP. aeruginosa surface proteinsP. aeruginosa porinsP. aeruginosa adhesinsP. aeruginosa TonB-dependent receptorsP. aeruginosa CSS receptors

LPS binding/disruption (e.g., colistin, polymyxin B); Inhibition of nutrient uptake (e.g., iron chelators block siderophore/ferripyoverdine receptors); Blocking biofilm formation (surface sensing/Wsp system inhibition); Disruption of cell signaling (targeting CSS pathways).