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Target intelligence / Profile preview
Pseudomonas aeruginosa Exopolysaccharide Psl (Psl)
- Target
- Psl
- Molecular classification
- Exopolysaccharide, Polysaccharide
01
Overview
Psl is an exopolysaccharide produced by the bacterium *Pseudomonas aeruginosa*. It is crucial for biofilm formation, structural integrity, and resistance to environmental stresses. Psl contributes to antimicrobial resistance, immune evasion, and host interaction. Its biosynthesis is regulated by intracellular levels of cyclic-di-GMP. Targeting Psl is a potential strategy for combating *P. aeruginosa* infections.
- Other names
- Psl exopolysaccharidePsl polysaccharide
02
Mechanism of action
Inhibition of Psl synthesis; disruption of Psl structure; targeting biofilm formation
03
Biological functions
Biofilm formationCell-cell interactionAntimicrobial resistanceImmune evasionAdhesion
04
Disease associations
InfectionPseudomonas aeruginosa infectionChronic infection
05
Safety considerations
Potential for off-target effects on other bacterial polysaccharidesDevelopment of resistance to Psl-targeting therapies
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