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Pseudomonas aeruginosa Exotoxin A (PE)

Target: PE
Molecular classification: Toxin, Enzyme, ADP-ribosyltransferase

Overview

Pseudomonas aeruginosa exotoxin A (PE), also known as exotoxin A or ETA, is a potent protein toxin secreted by the Gram-negative bacterium Pseudomonas aeruginosa. It inhibits protein synthesis in eukaryotic cells by ADP-ribosylating eukaryotic elongation factor 2 (eEF2). While primarily known for its role in bacterial pathogenesis, modified forms of PE have been engineered into immunotoxins for targeted cancer therapy.

Other names: Exotoxin AETA

Mechanism of action

ADP-ribosylation of eukaryotic elongation factor 2 (eEF2), leading to inhibition of protein synthesis and cell death.

Biological functions

Inhibition of protein synthesisCell deathADP-ribosylation of eEF2

Disease associations

InfectionPneumoniaSepsisCancer (in engineered forms)

Safety considerations

ImmunogenicityOff-target effects (in engineered forms)High toxicity

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