Pseudomonas aeruginosa serotype O11 lipopolysaccharide O-polysaccharide (P. aeruginosa O11 O-antigen)

Pseudomonas aeruginosa serotype O11 lipopolysaccharide O-polysaccharide, also known as the O-antigen, is a highly variable carbohydrate chain extending from the outer membrane of the bacterium. It serves as a primary determinant of serological specificity and is a critical virulence factor that shields the pathogen from the host's innate immune system, particularly complement-mediated lysis and phagocytosis [1][2]. The O11 serotype is one of the most prevalent strains associated with severe hospital-acquired infections, including ventilator-associated pneumonia [3]. This molecule is a major therapeutic target for monoclonal antibodies and vaccines designed to provide serotype-specific immunity. For instance, Panobacumab is a human monoclonal IgM antibody that specifically targets the O11 O-polysaccharide to enhance opsonophagocytic killing by host neutrophils [4]. While highly effective against its specific target, the therapeutic utility of targeting this molecule is limited by the high degree of structural diversity among the 20 different International Antigenic Typing Scheme (IATS) serotypes of P. aeruginosa [5]. Sources: [1] Pier, G. B. (2007). Pseudomonas aeruginosa lipopolysaccharide: a major virulence factor and drug target. Pseudomonas, 361-385. [2] Knirel, Y. A., et al. (2006). Revision of the structure of the O-polysaccharide of Pseudomonas aeruginosa O11. Carbohydrate Research, 341(14), 2431-2434. [3] Que, Y. A., et al. (2014). Assessment of panobacumab as adjuvant immunotherapy in Pseudomonas aeruginosa O11 pneumonia. European Respiratory Journal, 43(5), 1430-1439. [4] Horn, M. P., et al. (2010). Panobacumab, a human monoclonal IgM antibody, for adjuvant treatment of Pseudomonas aeruginosa serotype O11 pneumonia. Critical Care, 14(1), R15. [5] Stanislavsky, E. S., & Lam, J. S. (1997). Pseudomonas aeruginosa antigens as potential vaccines. FEMS Microbiology Reviews, 21(3), 243-277.

Other names

O11 antigenO11 O-specific polysaccharidePseudomonas aeruginosa O11 LPSO11-specific lipopolysaccharideIATS O11 O-antigen

Promotion of opsonophagocytosis, complement activation, and neutralization of bacterial surface-mediated immune evasion by binding to the specific O-antigen repeating units.