Pseudomonas aeruginosa surface receptors

Pseudomonas aeruginosa surface receptors represent a broad class of proteins and glycoconjugates situated on the outer membrane of the bacterium that facilitate interaction with the external environment. This category includes porins like OprD, which regulate antibiotic entry, siderophore receptors such as FpvA involved in iron acquisition, and adhesins like Type IV pili and lectins (LecA/LecB) that mediate attachment to host tissues [Wagner et al., 2016, Molecules; Galdiero et al., 2012, Current Protein & Peptide Science]. These receptors are fundamental to the pathogen's virulence, enabling the formation of biofilms and the evasion of the host immune system, particularly in chronic respiratory infections like those seen in cystic fibrosis [DiGiandomenico et al., 2014, Science Translational Medicine; UniProt, 2023]. Therapeutically, these surface structures are highly significant as they are accessible to large molecules; for instance, monoclonal antibodies like MedI3902 target surface polysaccharides and proteins to enhance bacterial clearance [DiGiandomenico et al., 2014, Science Translational Medicine]. Additionally, Trojan horse antibiotics like cefiderocol exploit siderophore receptors to bypass traditional resistance mechanisms, highlighting the dual role of these receptors as both virulence factors and gateways for drug delivery [Shizuma, 2022, Antibiotics].

Other names

P. aeruginosa outer membrane proteinsPseudomonas surface antigensP. aeruginosa adhesinsPseudomonas porins

Inhibition of bacterial adhesion, disruption of nutrient acquisition via siderophore mimicry, and neutralization of the type III secretion system machinery [Shizuma, 2022, Antibiotics; DiGiandomenico et al., 2014, Science Translational Medicine; Wagner et al., 2016, Molecules].