Target intelligence / Profile preview

Pseudomonas aeruginosa Type III Secretion System Protein PcrV (PcrV)

Target: PcrV
Molecular classification: Type III Secretion System Component, Virulence Factor

Overview

PcrV is a key protein component of the type III secretion system (T3SS) in *Pseudomonas aeruginosa*. It forms the needle-tip complex of the T3SS translocon, which is essential for delivering effector proteins into host cells. PcrV interacts with chaperone protein PcrG within *P. aeruginosa*. Antibodies against PcrV have shown promise in protecting against *P. aeruginosa* infections, making it an attractive target for immunotherapy or vaccine development. Small molecules that block interactions involving PcrV can disrupt effector translocation.

Mechanism of action

Inhibition of T3SS-mediated toxin delivery by blocking assembly or function at the needle tip.

Biological functions

T3SS translocon formationEffector protein translocationHost cell intoxication

Disease associations

InfectionSepsis

Interacting drugs

COT-143

2 more in the full profile.

Biomarkers

Circulating anti-PcrV antibodies (protective)Free circulating PcrV antigen (diagnostic)

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