Target intelligence / Profile preview

Pseudomonas Exotoxin A (PE)

Target: PE
Molecular classification: Toxin, Enzyme

Overview

Pseudomonas exotoxin A (PE), also known as exotoxin A or ETA, is a potent extracellular toxin produced by Pseudomonas aeruginosa. It inhibits protein synthesis in eukaryotic cells by ADP-ribosylating elongation factor 2 (eEF2). Modified forms are used as cytotoxic payloads in immunotoxins targeting cancer cells.

Other names: Exotoxin AETA

Mechanism of action

ADP-ribosylation of eukaryotic elongation factor 2 (eEF2), leading to protein synthesis inhibition.

Biological functions

Protein synthesis inhibitionCell deathADP-ribosylation of eEF2

Disease associations

InfectionCancer (as a cytotoxic payload)

Safety considerations

High toxicityOff-target effects when used in immunotoxins

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