Target intelligence / Profile preview

Pseudomonas syringae (P. syringae)

Target
P. syringae
Molecular classification
Bacterium, Gram-negative bacterium, Gammaproteobacteria
01

Overview

Pseudomonas syringae is a widespread Gram-negative bacterium and a major plant pathogen that affects a broad spectrum of agricultural crops and wild plants (Hirano & Upper, 2000). It is characterized by its ability to exist as an epiphyte on leaf surfaces before entering plant tissues through stomata or wounds to cause diseases such as bacterial speck, canker, and blight (Mansfield et al., 2012). A defining feature of many P. syringae strains is the production of ice nucleation proteins, which promote ice crystal formation at relatively high temperatures, leading to frost damage that facilitates bacterial entry (Lindow, 1987). The bacterium employs a type III secretion system to deliver effector proteins into host cells, suppressing plant immunity and promoting nutrient release (Alfano & Collmer, 2004). While it is a critical target in agricultural biotechnology and crop protection, it is not a human therapeutic target or a specific molecular receptor. Management of P. syringae infections primarily relies on copper-based bactericides and specific antibiotics like streptomycin, although the rapid evolution of resistance remains a significant concern for global food security (Sundin & Wang, 2018).

Other names
P. syringaePseudomonas syringae groupPhytopathogenic Pseudomonas
02

Mechanism of action

Antibiotics like streptomycin and oxytetracycline inhibit bacterial protein synthesis by binding to the 30S ribosomal subunit (Sundin & Wang, 2018). Copper-based bactericides act by releasing Cu2+ ions that denature proteins and disrupt cell membranes through oxidative stress (Lamichhane et al., 2018).

03

Biological functions

Plant pathogenesisIce nucleationEpiphytic growthType III secretionQuorum sensing
04

Disease associations

Bacterial speckBacterial cankerBacterial blightLeaf spotInfection
05

Safety considerations

Development of antibiotic resistance in plant pathogens and potential horizontal gene transfer to human pathogens (Sundin & Wang, 2018)Environmental accumulation and toxicity of copper in soil and water (Lamichhane et al., 2018)Phytotoxicity of certain chemical treatments
06

Interacting drugs

Streptomycin

4 more in the full profile.

07

Biomarkers

Ice nucleation protein (InaZ)Type III effector proteins (e.g., AvrPto, HopA1)Coronatine phytotoxinhrp gene expression

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