Pseudouridine synthase 7 (PUS7)

Pseudouridine synthase 7 (PUS7) is an opportunistic and highly versatile RNA modification enzyme belonging to the pseudouridine synthase (TruD) family[3][1]. It catalyzes the conversion of uridine to pseudouridine (Ψ) in a broad range of RNA substrates, including messenger RNA (mRNA), transfer RNA (tRNA), and noncoding RNAs[1][2][3]. Unlike other family members, PUS7 recognizes many substrates with variable sequences and structures, but is especially active on less-structured RNAs containing the UGUAR consensus motif[1][2]. PUS7's enzymatic activity plays a critical role in regulating RNA stability and protein synthesis, allowing rapid cellular adaptation to stress or developmental cues[2][3]. Mutations in human PUS7 disrupt its function and cause developmental and intellectual disability syndromes, highlighting its biomedical importance[3]. The broad substrate specificity derives from structural features, including unique insertion domains that create an extended RNA-binding surface[3]. While PUS7 is not currently a direct drug target and no interacting drugs are known, its function is crucial for normal cellular physiology and holds relevance for disease biology.

Other names

Pseudouridylate synthase 7 homologPUS7KIAA1897FLJ20485IDDABSpseudouridylate synthase 7 homologpseudouridylate synthase 7 (putative)TruD family pseudouridine synthase

Drugs would act by inhibiting enzymatic pseudouridylation of uridine to pseudouridine in target RNAs