Psl exopolysaccharide (Psl)

Psl exopolysaccharide is a neutral exopolysaccharide synthesized by the *pslA-O* operon in *Pseudomonas aeruginosa*. It is essential for initial surface attachment and the maintenance of biofilm microstructure, providing mechanical stability and protection against antimicrobials and the host immune system. Psl is composed primarily of mannose, galactose, glucose, and rhamnose in a pentasaccharide repeating unit and is a major target for strategies aiming to prevent or disrupt biofilm-mediated infections, especially in cystic fibrosis and hospital-acquired infections[1][3][4][6][7].

Other names

Psl polysaccharidePsl matrix polysaccharide

Agents targeting Psl may inhibit exopolysaccharide synthesis (e.g., inhibitors of the Psl synthetic operon), disrupt established biofilm matrices, or enhance susceptibility of bacteria to antibiotics.