PSMA5 pseudogene 1 (PSMA5P1)

PSMA5 pseudogene 1 (PSMA5P1) is annotated as a pseudogene related to PSMA5, which means it is generally a non-coding DNA fragment resembling the protein-coding gene PSMA5. There is no evidence of it encoding a functional protein or serving as a therapeutic or pharmacological target. The protein-coding parent gene, PSMA5 (proteasome subunit alpha type-5), is an essential component of the 20S proteasome complex, responsible for the regulated degradation of most intracellular proteins as part of the ubiquitin-proteasome system[1][3][4][5][6]. Dysfunction in proteasome activity (including its subunits) is associated with diseases such as cancers, neurodegenerative disorders, and autoimmune conditions, and is a target of several cancer drugs. However, no such functional or therapeutic relevance is attributed to PSMA5P1.