Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Psoralen Receptor
- Molecular classification
- Receptor, Membrane protein, Cytoplasmic protein
01
Overview
The psoralen receptor is a ~22 kDa protein found in the cell membrane and cytoplasm of various cell types, including skin cells. It binds psoralens, such as 8-MOP, and upon UVA photoactivation, triggers cellular responses like altered proliferation and melanogenesis. It also modulates signaling pathways like EGF receptor, PI3K/Akt, and estrogen receptor signaling, influencing its potential use in treating skin diseases and cancer.
- Other names
- 8-MOP ReceptorPsoralen binding protein
02
Mechanism of action
Psoralens bind to a ~22 kDa receptor in the cell membrane or cytoplasm. Upon UVA exposure, the psoralen-receptor complex is photoactivated, leading to photoalkylation of the receptor and downstream signaling changes that affect cell proliferation, differentiation, and melanogenesis. Can also modulate hormone receptor pathways (e.g. estrogen receptor) and P-glycoprotein.
03
Biological functions
Signal transductionCell proliferation regulationMelanogenesisEGF receptor modulationEstrogen signaling modulation
04
Disease associations
Skin diseases (e.g., psoriasis, vitiligo)Cancer (potential anti-tumor effects via ErbB2 and ERα modulation)
05
Safety considerations
PhotosensitivityPotential for drug interactions (e.g., affecting P-gp activity)Mutagenicity (psoralens can intercalate into DNA)
06
Interacting drugs
Psoralens (e.g., 8-Methoxypsoralen (8-MOP))
3 more in the full profile.
Beyond the preview
Go deeper on Psoralen Receptor.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Psoralen Receptor.