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Psoriasis-associated non-protein coding RNA induced by stress (PRINS)

Target: PRINS
Molecular classification: Long non-coding RNA

Overview

Psoriasis-associated non-protein coding RNA induced by stress (PRINS) is a long non-coding RNA (lncRNA) that plays a significant role in the pathogenesis of psoriasis and cellular stress responses. It is upregulated in response to cellular stress and regulates the expression of G1P3 (IFI6), an anti-apoptotic protein, thereby modulating keratinocyte survival. PRINS binds to nucleophosmin (NPM), impacting cellular response to environmental stress.

Biological functions

Stress responseRegulation of apoptosisCell survivalModulation of anti-apoptotic pathways

Disease associations

Psoriasis

Biomarkers

PRINS expression levels in psoriatic lesions

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