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Target intelligence / Profile preview
Psoriasis susceptibility 1 candidate 1 (PSORS1C1)
- Target
- PSORS1C1
- Molecular classification
- Other (Protein of currently undefined family or function)
01
Overview
Psoriasis susceptibility 1 candidate 1 (PSORS1C1) is a protein-coding gene located on chromosome 6p21.33 in the major histocompatibility complex (MHC) class I region, near genetic loci critical for immune function. It is an orphan gene with no clearly characterized protein products or molecular function according to protein databases and the Human Protein Atlas. PSORS1C1 has been repeatedly implicated by genome-wide association studies as a susceptibility locus for psoriasis and systemic sclerosis, as well as certain other autoimmune and skin disorders, but there is no evidence that it encodes a classical receptor, enzyme, or druggable target. No drugs directly interact with or target PSORS1C1, and its function, localization, and pathway involvement remain largely speculative in the published literature as of this date.
- Other names
- C6orf16SEEK1Epididymis secretory sperm binding proteinPsoriasis susceptibility 1 candidate gene 1 protein
02
Mechanism of action
None established (no therapeutics directly target, or mechanism not described in current literature)
03
Biological functions
Putative involvement in immune response or autoimmune disease susceptibility, particularly in psoriasis and systemic sclerosis, based on genetic association studiesUnknown/uncategorized molecular function (current annotation)
04
Disease associations
Autoimmune disease (notably psoriasis and systemic sclerosis)Hypotrichosis 2Peeling skin syndrome 1Autoimmune thyroid disease
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