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Target intelligence / Profile preview
Psoriasis susceptibility 1 candidate gene 2 protein (PSORS1C2)
- Target
- PSORS1C2
- Molecular classification
- Other
01
Overview
Psoriasis susceptibility 1 candidate gene 2 protein (PSORS1C2) is a small mammalian protein (14.4 kDa) encoded by the PSORS1C2 gene located within the major histocompatibility complex (MHC) region on chromosome 6, between the CCHCR1 and CDSN genes[1][2][3][11]. PSORS1C2 is highly expressed in human epidermis, particularly in the granular layer and during terminal differentiation of keratinocytes, with weak expression in the thymus[2]. It has been defined as a keratinocyte cornification-associated protein and has evolutionary presence primarily in mammals[2]. Mutations or regulatory variations of PSORS1C2 are associated with increased susceptibility to psoriasis, but there is currently no evidence that it is a direct therapeutic target or that any approved drugs act on this protein[2][3][11].
- Other names
- C6orf17SPR1Chromosome 6 open reading frame 17Protein SPR1Psoriasis susceptibility 1 candidate 2
02
Biological functions
Epidermal differentiationKeratinocyte cornificationTerminal differentiation of keratinocytes
03
Disease associations
PsoriasisPsoriasis 9
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