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PSPC1 antisense RNA 2 (PSPC1-AS2)

Target
PSPC1-AS2
Molecular classification
Long non-coding RNA
01

Overview

PSPC1 antisense RNA 2 (PSPC1-AS2) is a human long non-coding RNA, located on chromosome 13, transcribed antisense to the gene coding for Paraspeckle component 1 (PSPC1). While PSPC1 is a well-characterized RNA-binding protein involved in gene expression regulation, phase separation in nuclear paraspeckles, and cancer progression[1][2][3][4], there are currently no detailed functional or disease associations described for PSPC1-AS2 itself in the biomedical literature. The current annotation for PSPC1-AS2 is based on gene locus characterization and genome references—no reports demonstrate its role as a receptor, enzyme, or drug target, nor document its expression in relation to pathology or therapeutics. Critical clarification: - Do not confuse PSPC1-AS2 with PSPC1. - PSPC1 (Paraspeckle component 1) is a protein with well-established nuclear functions and clinical associations[1][2]; PSPC1-AS2 is a non-coding RNA with no established role as a molecular target or therapeutic intervention point as of 2024. - The current entry for PSPC1-AS2 is accurate and not a misannotation, but it should not be treated as a classical drug target.

Other names
RP11-523H24.3PSPC1-AS2
02

Mechanism of action

Not applicable; no direct drugs or mechanism of action established

03

Biological functions

Not well defined; as an antisense RNA to Paraspeckle component 1 (PSPC1), it may be involved in gene regulation at the RNA level, potentially through transcriptional or post-transcriptional modulation.
04

Disease associations

Not well established. There is no published literature directly linking PSPC1-AS2 to specific diseases as of 2024, but antisense RNAs can commonly be involved in cancer biology or other gene regulation-associated diseases by modulating the sense gene's expression.

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