PTB domain-containing engulfment adapter protein 1 (GULP1)

PTB domain-containing engulfment adapter protein 1 (GULP1) is a highly conserved cytoplasmic adapter protein essential for the phagocytosis of apoptotic cells by phagocytes[1][7]. It acts by binding to NPXY motifs found in the cytoplasmic tails of various engulfment receptors via its phosphotyrosine-binding (PTB) domain, thereby linking these receptors (such as stabilin-1, stabilin-2, Jedi-1, and low-density lipoprotein receptor family members) to intracellular signaling pathways regulating actin cytoskeletal remodeling and endocytosis[1][8]. GULP1 is involved not only in cellular clearance but also in modulating glycosphingolipid and cholesterol transport, endosomal trafficking, and regulating amyloid precursor protein (APP) processing, influencing amyloid-β generation[1][3][5][7]. Differential expression and function of GULP1 have been implicated in neurodegenerative diseases (e.g., Alzheimer’s disease), various cancers as a potential biomarker and modulator of tumor immune response, and rare metabolic disorders[2][5][7]. While recognized as biologically relevant to disease processes, GULP1 is not currently identified as a direct therapeutic target or druggable enzyme, receptor, or transporter.

Other names

GULP1GULPCED-6CED6Cell death protein 6 homologPTB domain adapter protein CED-6Engulfment adaptor PTB domain containing 1Protein GULP