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Pteridine Reductase 1 (None established)

Target: None established
Molecular classification: Enzyme

Overview

Pteridine reductase 1 (PTR1) is an NADPH-dependent enzyme found in Leishmania species, protozoan parasites responsible for leishmaniasis. PTR1 plays a crucial role in the salvage and reduction of pteridines, compounds essential for parasite growth and survival, because Leishmania are auxotrophic for these molecules. Inhibition of PTR1 is a potential therapeutic strategy, but the redundancy with DHFR means dual inhibition may be required. Upregulation of PTR1 confers resistance against antifolate drugs.

Other names: PTR1

Mechanism of action

Enzyme inhibition

Biological functions

Reduction/salvage of pteridinesSupports folate metabolism

Disease associations

Infection

Safety considerations

Potential for off-target effectsDevelopment of drug resistance

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