Pteridine Synthetase (None)

Pteridine synthetase refers to a family of enzymes involved in the biosynthesis and modification of pteridines, essential heterocyclic compounds. These enzymes play crucial roles in folate synthesis, tetrahydrobiopterin production, and other metabolic processes. Dihydropteroate synthetase, a key member of this group, is a target for sulfonamide antibiotics, which inhibit bacterial folate synthesis. In humans, pteridine biosynthetic enzymes regulate tetrahydrobiopterin levels, which are vital for the function of aromatic amino acid hydroxylases and nitric oxide synthases.

Other names

Dihydropteroate synthetaseGTP-cyclohydrolase I6-Pyruvoyltetrahydropterin synthasePTPSGTPCH I

Inhibition of dihydropteroate synthetase, blocking folate synthesis