Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Pterin-4-alpha-carbinolamine dehydratase 2 (PCBD2)
- Target
- PCBD2
- Molecular classification
- Enzyme
01
Overview
Pterin-4-alpha-carbinolamine dehydratase 2 (PCBD2) is an enzyme involved in tetrahydrobiopterin biosynthesis. It also functions as a dimerization cofactor for hepatocyte nuclear factor 1 alpha (HNF-1-alpha), enhancing transcriptional activity. PCBD2 is implicated in several diseases, including cancer and genetic disorders like Noonan Syndrome 9 and hyperphenylalaninemia. It is primarily located in the mitochondria but can shuttle between cytoplasm and nucleus to exert its effects. PCBD2 is not a conventional ion channel but may serve as a regulatory or scaffolding element in various cellular processes[1][2][3].
- Other names
- DCOH2DCOHMPHS2Dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 24-alpha-hydroxy-tetrahydropterin dehydratase 26-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2
02
Biological functions
Tetrahydrobiopterin biosynthesisRegulation of DNA-templated transcriptionDimerization of homeodomain protein HNF-1-alpha
03
Disease associations
Cancer (e.g., rectal cancer)Noonan Syndrome 9Hyperphenylalaninemia
Beyond the preview
Go deeper on Pterin-4-alpha-carbinolamine dehydratase 2 (PCBD2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Pterin-4-alpha-carbinolamine dehydratase 2 (PCBD2).