Target intelligence / Profile preview

Pudendal nerve

Molecular classification
Other (Peripheral nerve)
01

Overview

The **pudendal nerve** is the principal somatic nerve of the perineum, originating from sacral plexus roots S2–S4. It is a mixed sensory and motor nerve, supplying sensation to the external genitalia (penis, clitoris, scrotum, labia), the anus and perineal region, and providing motor control to the external anal and urethral sphincters and pelvic floor muscles. Its functions include mediation of urinary and fecal continence, sexual function (including erection and ejaculation), and perineal sensory input. Injury or entrapment can result in neuropathic pain or functional deficits such as incontinence or sexual dysfunction. Clinically, it is also the target for pudendal nerve blocks for perineal pain management, especially during childbirth[1][2][3][5].

Other names
PudendalMain nerve of the perineumNerve of the pelvic floorNerve of the perineal region
02

Mechanism of action

Blockade of nerve transmission (e.g., via local anesthesia inhibits sensory and motor function for pain relief or surgical procedures)

03

Biological functions

Sensory transmission from external genitalia, anus, anal canal, and perineumMotor innervation of external anal and urethral sphinctersMotor control of pelvic floor musclesControl of urinary and fecal continenceInvolved in sexual function (affects erection and ejaculation)
04

Disease associations

Pelvic pain syndromesPudendal neuralgia (neuropathic pain)Incontinence (urinary and fecal)Sexual dysfunction (erectile and ejaculatory disorders)Childbirth injury-associated deficits
05

Safety considerations

Risk of nerve damage during childbirth or pelvic surgery; leads to incontinence or sexual dysfunctionLocal anesthetic complications (nerve block)Pudendal entrapment neuropathy, causing chronic pain (pudendal neuralgia)Difficulty in diagnosis and management of neuropathic pain syndromes
06

Interacting drugs

Local anesthetics (lidocaine, bupivacaine, etc., used in pudendal nerve block)

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