Target intelligence / Profile preview

Pulmonary Surfactant Protein B (None)

Target: None
Molecular classification: Saposin-like protein

Overview

Pulmonary surfactant protein B (SP-B) is a small, hydrophobic protein essential for lung function. It reduces alveolar surface tension, preventing collapse during exhalation. SP-B interacts with lipids, stabilizes surfactant structure, and is critical for surfactant recycling and homeostasis. Mutations or deficiencies in SP-B cause hereditary neonatal respiratory distress syndrome. Synthetic or natural SP-B is used in exogenous surfactants for treating RDS.

Other names: SP-BSFTPBproSP-B (precursor)

Mechanism of action

Replicates the biophysical functions of native SP-B by lowering alveolar surface tension and facilitating surfactant spreading.

Biological functions

Surface tension reductionSurfactant structure stabilizationLipid interaction and organizationSurfactant recycling and homeostasis

Disease associations

Respiratory distress syndrome (RDS)Hereditary neonatal respiratory distress syndrome

Safety considerations

Potential for immune response to exogenous SP-BChallenges in manufacturing and delivery of functional SP-B analogs

Interacting drugs

Exogenous surfactants (containing SP-B analogs or extracts)

Biomarkers

SP-B levels in amniotic fluid (for fetal lung maturity)Genetic mutations in SFTPB (for diagnosis of hereditary RDS)

Beyond the preview

Go deeper on Pulmonary Surfactant Protein B (None).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Pulmonary Surfactant Protein B (None).

Explore the full profile