Pumilio RNA binding family member 2 (PUM2)

Pumilio RNA binding family member 2 (PUM2) is a member of the evolutionarily conserved PUF family of RNA-binding proteins, characterized by the presence of the Pumilio homology domain (PUM-HD) containing eight Puf repeats critical for RNA binding[4]. PUM2 regulates gene expression by binding to sequence motifs (such as the Pumilio Response Element: 5'-UGUANAUA-3') in the 3'-UTR of target mRNAs, leading to translational repression or mRNA degradation, often by recruitment of deadenylation complexes or by facilitating miRNA accessibility[1][2][3]. It interacts with DAZ and DAZL proteins and plays crucial roles in the development and maintenance of germ cells, embryogenesis, and neurogenesis[2][4]. While PUM2 is not currently recognized as a druggable therapeutic target and no approved drugs directly interact with it, its functions have been implicated in cell proliferation, fertility, and disease states such as cancer and neuronal disorders[1][2][3][4]. Key molecular features: Evolutionarily conserved, with homology across eukaryotes. Interacts with DAZ, DAZL, and other regulatory proteins in the germline. Regulates stability and translation of target mRNAs via PUF domain binding. Mainly located in the cytoplasm, especially in embryonic and germ cells[2]. PUM2 has extensive roles as a post-transcriptional regulator but is not currently a direct therapeutic target.

Other names

Pumilio homolog 2PUM2KIAA0235PUMH2Pumilio-2PUML2