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Purine Nucleoside Analog

Molecular classification: Antimetabolite, Anticancer agent, Immunomodulator, Nucleoside Analog

Overview

Purine nucleoside analogs are synthetic molecules structurally similar to natural purine nucleosides. They act as antimetabolites, disrupting DNA and RNA synthesis by incorporating into nucleic acids and causing chain termination or inhibiting further elongation. These analogs are used as anticancer agents, particularly in hematologic malignancies, and some have immunosuppressive properties.

Mechanism of action

Inhibition of DNA/RNA synthesis via incorporation, chain termination, and apoptosis induction after intracellular activation (phosphorylation).

Biological functions

Inhibition of DNA synthesisInhibition of RNA synthesisDNA repair disruptionApoptosis inductionImmunosuppression

Disease associations

CancerAutoimmune diseaseOrgan transplantation rejectionInfection

Safety considerations

MyelosuppressionImmunosuppressionOpportunistic infectionsSecondary malignancies

Interacting drugs

Mercaptopurine

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