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Purine-nucleoside phosphorylase (PNP)
- Target
- PNP
- Molecular classification
- Enzyme
01
Overview
Purine-nucleoside phosphorylase (PNP) is an enzyme that catalyzes the reversible phosphorolysis of purine nucleosides into their corresponding purine bases and ribose 1-phosphate or deoxyribose 1-phosphate. It plays a crucial role in purine salvage and is essential for nucleotide homeostasis. Deficiency in PNP leads to immunodeficiency and other disorders, making it a drug target for modulating immune responses in cancer chemotherapy and autoimmune diseases.
- Other names
- Inosine phosphorylasePNPasePUNPIPUNPIIInosine-guanosine phosphorylaseNucleotide phosphatase
02
Mechanism of action
Inhibition of PNP activity
03
Biological functions
Purine metabolismPyrimidine metabolismNicotinate and nicotinamide metabolismNucleotide homeostasisImmune regulation
04
Disease associations
ImmunodeficiencyAutoimmune disordersCancerRecurrent Infections
05
Safety considerations
Profound T-cell immunodeficiencyNeurological symptoms (developmental delay, ataxia)Increased risk for autoimmune disorders
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